Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers: A 31 P MRS study at 7T.
Andrew AppsLadislav ValkovičMark PeterzanJustin Y C LauMoritz HundertmarkWilliam T ClarkeElizabeth M TunnicliffeJane EllisDamian J TylerStefan NeubauerOliver J RiderChristopher T RodgersAlbrecht Ingo SchmidPublished in: Magnetic resonance in medicine (2020)
We introduced a method that can resolve Pi using 7 Tesla STEAM 31 P-MRS. We demonstrate the stability of Pi/PCr and myocardial pH in volunteers at rest and during catecholamine stress. This protocol is feasible in patients and potentially of use for studying pathological myocardial energetics.