Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.
Judith LechnerMei ChenRuth E HoggLevente TothGiuliana SilvestriUsha ChakravarthyHeping XuPublished in: Immunity & ageing : I & A (2016)
Our results suggest increased systemic complement activation in nAMD patients with CNV but not RAP and PCV. Our results also suggest that higher levels of systemic complement activation may increase the risk of subretinal fibrosis in nAMD patients.