Heping Xu

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 34

Top Venues

International journal of molecular sciences

Nature communications

Cells

Biomedicines

Queen's University Belfast

Hunan Medical University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Queen's University Belfast Sep 01 2013

United Kingdom

Professor :: Centre for Experimental Medicine

Queen's University Belfast Oct 01 2011 - Oct 01 2013

United Kingdom

Reader :: Centre for Vision and Vascular Science

Queen's University Belfast Sep 01 2009 - Oct 01 2011

United Kingdom

Senior Lecturer :: Centre for Vision and Vascular Science

University of Aberdeen Apr 01 2008 - Aug 31 2009

United Kingdom

Senior ECUK Fellow :: Infection and Immunity

University of Aberdeen Apr 01 2005 - Mar 31 2008

United Kingdom

RCUK Fellow :: Ophthalmology

University of Aberdeen Feb 01 2000 - Mar 31 2005

United Kingdom

Post-doctoral Research Fellow :: Ophthalmology

Seikagaku Corporation Sep 01 1997 - Jan 29 2000

Japan

Post-Doc Research Scientist :: Department of Exploratory Reserach

Hunan Medical University Jul 01 1994 - Aug 31 1994

China

Assistant Professor :: Ophthalmology

Education History

Hunan Medical University Sep 01 1989 - Jul 01 2004

China

PHD :: Ophthalmology

Publications

Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J Lyons, Nicholas M Barnes, Parth Narendran, Janet M Lord, Saaeha Rauz, Ian G Ganley, Tim M Curtis, Graham R Wallace, Jose R Hombrebueno
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status. Nature communications 15 (1) (2024)
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J Lyons, Nicholas M Barnes, Parth Narendran, Janet M Lord, Saaeha Rauz, Ian G Ganley, Tim M Curtis, Graham R Wallace, Jose R Hombrebueno
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status. Nature communications 15 (1) (2024)
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J Lyons, Nicholas M Barnes, Parth Narendran, Janet M Lord, Saaeha Rauz, Ian G Ganley, Tim M Curtis, Graham R Wallace, Jose R Hombrebueno
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status. Nature communications 15 (1) (2024)
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J Lyons, Nicholas M Barnes, Parth Narendran, Janet M Lord, Saaeha Rauz, Ian G Ganley, Tim M Curtis, Graham R Wallace, Jose R Hombrebueno
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status. Nature communications 15 (1) (2024)
Xue Dong, Yinting Song, Yuming Liu, Xuejing Kou, Tianjing Yang, Samuel X Shi, Kai He, Yiming Li, Ziqi Li, Xueming Yao, Ju Guo, Bohao Cui, Ziru Wu, Yi Lei, Mei Du, Mei Chen, Heping Xu, Qiang Liu, Fu-Dong Shi, Xiaohong Wang, Hua Yan
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice. Science translational medicine 16 (760) (2024)
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J Lyons, Nicholas M Barnes, Parth Narendran, Janet M Lord, Saaeha Rauz, Ian G Ganley, Tim M Curtis, Graham R Wallace, Jose R Hombrebueno
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status. Nature communications 15 (1) (2024)
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study. Cells 12 (3) (2023)
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study. Cells 12 (3) (2023)
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study. Cells 12 (3) (2023)
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study. Cells 12 (3) (2023)
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study. Cells 12 (3) (2023)
Josy Augustine, Sofia Pavlou, Kevin Harkin, Alan W Stitt, Heping Xu, Mei Chen
IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy. Disease models & mechanisms 16 (9) (2023)
Jinyan Qi, Wei Pan, Ting Peng, Ling Zeng, Xiaoning Li, Zhongping Chen, Zhikuan Yang, Heping Xu
Higher Circulating Levels of Neutrophils and Basophils Are Linked to Myopic Retinopathy. International journal of molecular sciences 24 (1) (2022)
Xuan Du, Eimear M Byrne, Mei Chen, Heping Xu
Minocycline Inhibits Microglial Activation and Improves Visual Function in a Chronic Model of Age-Related Retinal Degeneration. Biomedicines 10 (12) (2022)
Xuan Du, Eimear M Byrne, Mei Chen, Heping Xu
Minocycline Inhibits Microglial Activation and Improves Visual Function in a Chronic Model of Age-Related Retinal Degeneration. Biomedicines 10 (12) (2022)
Jinyan Qi, Wei Pan, Ting Peng, Ling Zeng, Xiaoning Li, Zhongping Chen, Zhikuan Yang, Heping Xu
Higher Circulating Levels of Neutrophils and Basophils Are Linked to Myopic Retinopathy. International journal of molecular sciences 24 (1) (2022)
Kevin Harkin, Josy Augustine, Alan W Stitt, Heping Xu, Mei Chen
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway. Biomedicines 10 (2) (2022)
Jinyan Qi, Wei Pan, Ting Peng, Ling Zeng, Xiaoning Li, Zhongping Chen, Zhikuan Yang, Heping Xu
Higher Circulating Levels of Neutrophils and Basophils Are Linked to Myopic Retinopathy. International journal of molecular sciences 24 (1) (2022)
Iswariyaraja Sridevi Gurubaran, Hanna Heloterä, Stephen Marry, Ali Koskela, Juha M T Hyttinen, Jussi J Paterno, Arto Urtti, Mei Chen, Heping Xu, Anu Kauppinen, Kai Kaarniranta
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a Independent of C3. Biology 10 (7) (2021)
Eimear M Byrne, María Llorián-Salvador, Miao Tang, Andriana Margariti, Mei Chen, Heping Xu
IL-17A Damages the Blood-Retinal Barrier through Activating the Janus Kinase 1 Pathway. Biomedicines 9 (7) (2021)
Eimear M Byrne, María Llorián-Salvador, Timothy J Lyons, Mei Chen, Heping Xu
Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes. International journal of molecular sciences 22 (21) (2021)
Janusz Blasiak, Ali Koskela, Elżbieta Pawłowska, Mikko P K Liukkonen, Johanna Ruuth, Elisa Toropainen, Juha M T Hyttinen, Johanna Viiri, John E Eriksson, Heping Xu, Mei Chen, Szabolcs Felszeghy, Kai Kaarniranta
Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice. International journal of molecular sciences 22 (4) (2021)
Ling Zeng, Xiaoning Li, Jian Liu, Hong Liu, Heping Xu, Zhikuan Yang
RNA-Seq Analysis Reveals an Essential Role of the Tyrosine Metabolic Pathway and Inflammation in Myopia-Induced Retinal Degeneration in Guinea Pigs. International journal of molecular sciences 22 (22) (2021)
Xuan Du, Rosana Penalva, Karis Little, Adrien Kissenpfennig, Mei Chen, Heping Xu
Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy. Molecular neurodegeneration 16 (1) (2021)
Karis Little, Maria Llorián-Salvador, Miao Tang, Xuan Du, Stephen Marry, Mei Chen, Heping Xu
Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration. Journal of neuroinflammation 17 (1) (2020)
Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy, Heping Xu
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis. Immunity & ageing : I & A 17 (1) (2020)
Jian Liu, Miao Tang, Kevin Harkin, Xuan Du, Chang Luo, Mei Chen, Heping Xu
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation. Journal of neuroscience research 98 (7) (2020)
Sofia Pavlou, Josy Augustine, Rónán Cunning, Kevin Harkin, Alan W Stitt, Heping Xu, Mei Chen
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7. International journal of molecular sciences 20 (9) (2019)
Judith Lechner, Jose R Hombrebueno, Edoardo Pedrini, Mei Chen, Heping Xu
Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2Akita diabetic mice. Diabetes & vascular disease research 16 (5) (2019)
Yong Luo, Jianbo Wan, Chang Luo, HengWei Liu, YuFan Zhou, Heping Xu, Zhong-Ping Chen
Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy. The British journal of ophthalmology 105 (7) (2019)
Marialaura Amadio, Kai Kaarniranta, Heping Xu, Adrian Smedowski, Deborah A Ferrington
Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxidative medicine and cellular longevity 2018 (2018)
Dinusha Rajapakse, Tim Curtis, Mei Chen, Heping Xu
Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture. Oxidative medicine and cellular longevity 2017 (2017)
Judith Lechner, Mei Chen, Ruth E Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy, Heping Xu
Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8). Journal of neuroinflammation 14 (1) (2017)
Judith Lechner, Mei Chen, Ruth E Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy, Heping Xu
Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD. Immunity & ageing : I & A 13 (2016)
Gayathri Devarajan, Mei Chen, Elizabeth Muckersie, Heping Xu
Culture and characterization of microglia from the adult murine retina. TheScientificWorldJournal 2014 (2014)

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Publication Activity (10 Years)

Top Topics

Top Venues

Heping Xu