Mitigation of Trypanosoma congolense-Associated Anemia and Expression of Trans-sialidase (TconTS) Gene Variants by Eugenol.

Aisha IbrahimSuleiman AminuHumphrey Chukwuemeka NzelibeGloria Dada ChechetMohammed Auwal Ibrahim

Published in: Acta parasitologica (2023)

The oral administration of eugenol suppressed T. congolense proliferation and prevented some major pathologies associated with trypanosomiasis infection. The reversal of renal hypertrophy and splenomegaly by the compound in addition to the reduction in the expression level of the TconTS gene variants could explain the observed anemia ameliorative potential of the compound.

Keyphrases

copy number
poor prognosis
chronic kidney disease
genome wide
iron deficiency
climate change
binding protein
signaling pathway
genome wide identification
dna methylation
long non coding rna
risk assessment
gene expression