Chronic Activation of Tubulin Tyrosination Improves Heart Function.
Niels PietschChristina Y ChenSvenja KupschLucas BacmeisterBirgit GeertzMarisol Herera-RiveroBente SiebelsHanna VoßElisabeth KrämerIngke BrarenDirk WestermannHartmut SchlüterGiulia MeariniSaskia SchlossarekJolanda van der VeldenMatthew A CaporizzoDiana LindnerBenjamin L ProsserLucie CarrierPublished in: Circulation research (2024)
This study provides the first proof of concept that chronic activation of tubulin tyrosination in HCM mice and in human EHTs improves heart function and holds promise for targeting the nonsarcomeric cytoskeleton in heart disease.