Oxaliplatin activates P53/miR-34a/survivin axis in inhibiting the progression of gastric cancer cells.

Qiang GuoXin-Yuan WangYan-Chang ZhaiYong-Wei DongQing-Si He

Published in: Immunity, inflammation and disease (2024)

Oxaliplatin inhibits tumor growth, invasion, and metastasis by upregulating miR-34a, activating the expression of the upstream P53 gene, and driving the downregulation of survivin (P53/miR-34a/survivin axis) in BGC-823 gastric cancer cells.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
poor prognosis
signaling pathway
genome wide
copy number
dna methylation
genome wide identification