Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam).

Howard H FeldmanJosé A LuchsingerGabriel C LégerCurtis TaylorDiane M JacobsDavid P SalmonSteven D EdlandKaren MesserCarolyn RevtaSarah A FlowersKerry S JonesAlbert KoulmanKevin E YarasheskiPhilip B VergheseVenky VenkateshHenrik ZetterbergJanuary DurantJody-Lynn LupoGary E Gibsonnull null

Published in: PloS one (2024)

ClinicalTrials.gov identifier: NCT06223360, registered on January 25, 2024. https://classic.clinicaltrials.gov/ct2/show/NCT06223360.

Keyphrases

double blind
placebo controlled
clinical trial
phase iii
phase ii
computed tomography
image quality
randomized controlled trial
study protocol
dual energy
contrast enhanced
positron emission tomography
magnetic resonance imaging
mild cognitive impairment