[Activity of metabolic enzymes of saliva with neuroendocrine tumors of the lung of various degrees of malignancy.]

Up to the present time, problems of optimizing the methods of diagnosis and predicting the course of lung cancer, which occupies the leading positions in the structure of oncological diseases, remain topical. The purpose of the study was to study the characteristics of the activity of metabolic salivary enzymes in neuroendocrine tumors of the lung, depending on the degree of malignancy. In the casecontrol study, 156 people took part, divided into 2 groups: primary (neuroendocrine lung tumors, n=56) and control (conventionally healthy, n=100). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. Between-group differences were measured with the nonparametric test. It is shown that against the background of neuroendocrine lung tumors, metabolic changes are observed characterized by a decrease in the de Ritis coefficient (p=0.0350) and lactate dehydrogenase activity (p=0.0492), as well as an increase in activity of alanine aminotransferase (p=0.0114), alkaline phosphatase (p=0.0150) and α-amylase (p=0.0328). Statistically significant differences between neuroendocrine tumors of different degrees of malignancy (G1+G2 and G3) were detected for aminotransferases (ALT - p=0.0421; AST - p=0.0472); alkaline phosphatase (p=0.0454) and α-amylase (p=0.0263). A decrease in the activity of the enzymes studied against the background of the progression of the disease, including the presence of distant and regional metastasis is shown. The most promising is the study of the activity of salivary α-amylase for the diagnosis of neuroendocrine lung tumors of high degree of malignancy.