Local Injection for Treating Mood Disorders (LIFT-MOOD): A Pilot Feasibility RCT of Stellate Ganglion Block for Treatment-Resistant Depression.

David SussmanVanessa K TassoneFatemeh Gholamali NezhadMichelle WuFathima AdamsahibGabriella F MattinaJanneth Pazmino-CanizaresIlya DemchenkoHyejung JungWendy LouKarim S LadhaVenkat Bhat

Published in: Chronic stress (Thousand Oaks, Calif.) (2023)

This study supports the feasibility of a confirmatory trial of SGB in participants with TRD. Conclusions regarding efficacy cannot be made based on this preliminary study due to the small number of participants who completed active treatment. Larger-scale randomized controlled trials with long-term follow-ups and alternate sham procedures are needed to assess the efficacy and duration of symptom improvement with the use of SGB in TRD.

Keyphrases

randomized controlled trial
sleep quality
study protocol
depressive symptoms
systematic review
spinal cord injury
physical activity
phase ii
optical coherence tomography