Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity.
Jiamin ZhuShusen ChenBaixia YangWeidong MaoXi YangJing CaiPublished in: Bioscience reports (2019)
Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells regulation, epithelial-mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.
Keyphrases
- cell cycle arrest
- cell death
- early stage
- long non coding rna
- network analysis
- dna damage
- epithelial mesenchymal transition
- oxidative stress
- genome wide analysis
- locally advanced
- genome wide identification
- cancer stem cells
- radiation therapy
- pi k akt
- radiation induced
- endoplasmic reticulum stress
- signaling pathway
- risk assessment
- poor prognosis
- systematic review
- squamous cell carcinoma
- cell proliferation
- climate change
- current status