Increased SERPINB2 potentiates 15LO1 expression via STAT6 signalling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps.

Chunyu LuoYing ZhuShiyao ZhangJiayao ZhouSong MaoRu TangYuelong GuShaolin TanHai LinZhipeng LiWeitian Zhang

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)

SERPINB2 is increased in NP epithelial cells of eosinophilic CRSwNP (eCRSwNP) and contributes to T2 inflammation via STAT6 signalling. SERPINB2 could be considered a novel therapeutic target for eCRSwNP.

Keyphrases

chronic rhinosinusitis
cell proliferation
poor prognosis
oxidative stress