Natalizumab Treatment of Relapsing Remitting Multiple Sclerosis Has No Long-Term Effects on the Proportion of Circulating Regulatory T Cells.

Radu TanasescuNanci FrakichI-Jun ChouPerla FilippiniGiulio PoddaGao XinRanjithmenon MuraleedharanOltita JercaDavid OnionCris S Constantinescu

Published in: Neurology and therapy (2023)

We conclude that NTZ does not have an effect on the proportion of Treg cells over 1 year, but it may affect the expression of molecules important for some aspects MS pathogenesis, in a manner that is not shared with IFN-β1a.

Keyphrases

multiple sclerosis
regulatory t cells
dendritic cells
induced apoptosis
white matter
poor prognosis
cell cycle arrest
immune response
endoplasmic reticulum stress
oxidative stress
binding protein
rheumatoid arthritis
cell death
mass spectrometry
long non coding rna
ms ms