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Epigenetic regulation of thyroid hormone action in human metabolic dysfunction-associated steatohepatitis.

Alison-Michelle NaujackChristin KrauseJan H BritsemmerNatalie TaegeJens MittagHenriette Kirchner
Published in: European thyroid journal (2024)
miR-34a-5p constitutes a possible epigenetic master regulator of hepatic TH action, which together with THRB-specific DNA methylation could explain a possible developing TH resistance in the liver during MASH progression on the molecular level.
Keyphrases
  • dna methylation
  • endothelial cells
  • gene expression
  • genome wide
  • induced pluripotent stem cells
  • oxidative stress
  • transcription factor
  • pluripotent stem cells