Epigenetic regulation of thyroid hormone action in human metabolic dysfunction-associated steatohepatitis.
Alison-Michelle NaujackChristin KrauseJan H BritsemmerNatalie TaegeJens MittagHenriette KirchnerPublished in: European thyroid journal (2024)
miR-34a-5p constitutes a possible epigenetic master regulator of hepatic TH action, which together with THRB-specific DNA methylation could explain a possible developing TH resistance in the liver during MASH progression on the molecular level.