High plasma homocysteine level is associated with increased prevalence of non-remission state in rheumatoid arthritis: findings from the KURAMA cohort.

Increased plasma homocysteine levels showed a significant positive association with current disease activity and non-remission state in female patients with RA under T2T treatment. The findings suggest the potential utility of plasma homocysteine as a disease state marker reflecting conditions that are treatment failure and difficult to remission, and may provide clinical evidence on the interplay between homocysteine and inflammatory activation in RA.