Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study.
Ardalan EbrahimiShorook Na'araMoran AmitTzu-Chen YenChun-Ta LiaoPankaj ChaturvediJai Prakash AgarwalLuiz P KowalskiHugo F KöhlerMatthias KreppelClaudio R CerneaJason BrandaoGideon BacharAndrea Bolzoni VillaretDan M FlissEran FridmanKevin Thomas RobbinsJatin P ShahSnehal G PatelJonathan R Clarknull nullPublished in: Head & neck (2019)
The deterioration in prognosis with increasing DOI largely reflects an association with other adverse features. In the absence of these, depth alone should not be an indication for PORT outside a clinical trial.