Development and Internal Validation of a Clinical and Genetic Risk Score for Rheumatoid Arthritis-Associated Interstitial Lung Disease.
Austin M WheelerJoshua F BakerThomas RileyYangyuna YangPunyasha RoulKatherine D WyshamGrant W CannonGary KunkelGail KerrDana P AschermanPaul MonachAndreas ReimoldJill A PooleTony R MerrimanTed R MikulsBryant R EnglandPublished in: Rheumatology (Oxford, England) (2024)
A clinical and genetic risk model discriminated ILD in a large, multicentre RA cohort better than a clinical-only model, excluding 20% of the cohort from low-yield testing. These results demonstrate the potential utility of a GRS in RA-ILD and support further investigation into individualized risk stratification and screening.