The Incidence and Immunophenotypic and Genetic Features of JL1 Expressing Cells and the Therapeutic Potential of an Anti-JL1 Antibody in De Novo Pediatric Acute Leukemias.

Sang Hyuk ParkEunkyoung YouChan Jeoung ParkSeongsoo JangYoung Uk ChoChan Hee YoonKyung Nam KohHo Joon ImJong Jin Seo

Published in: Annals of laboratory medicine (2019)

Our findings support the potential therapeutic role of anti-JL1 monoclonal antibodies; JL1 expression was associated with specific immunophenotypes and genetic abnormalities. Future studies should examine the prognostic impact of JL1 expression in pediatric acute leukemias.

Keyphrases

poor prognosis
liver failure
respiratory failure
induced apoptosis
genome wide
drug induced
risk factors
cell cycle arrest
binding protein
copy number
current status
oxidative stress
signaling pathway
endoplasmic reticulum stress
extracorporeal membrane oxygenation
case control
pi k akt
childhood cancer