Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies.
Ziyan XieJunye ChenChenyu WangJiahao ZhangYanxiang WuXiaowei YanPublished in: Journal of molecular cell biology (2022)
Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.
Keyphrases
- extracellular matrix
- cell proliferation
- cardiovascular disease
- transcription factor
- healthcare
- oxidative stress
- randomized controlled trial
- risk assessment
- type diabetes
- gene expression
- electronic health record
- endothelial cells
- big data
- pi k akt
- artificial intelligence
- dna methylation
- vascular endothelial growth factor
- cardiovascular risk factors
- deep learning