Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.

Na LiMichael A LopezMaría LinaresSubodh KumarStefania OlivaJoaquin Martinez-LopezLian XuTommaso PeriniWilliam SenapedisErkan BalogluMasood A ShammasZachary R HunterKenneth C AndersonSteven P TreonNikhil C MunshiMariateresa Fulciniti

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

These results support the clinical investigation of KPT-9274 in combination with DNA-damaging agent for treatment of WM.

Keyphrases

circulating tumor
cell free
single molecule
nucleic acid
circulating tumor cells
replacement therapy