Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2.

Haruki Ujiie Naoyuki NishiyaAmi YamamotoTakeru TakadaMegumi OnoderaAyana SasakiTakuya Oikawa

Published in: Cancer chemotherapy and pharmacology (2024)

DEX protects hair cells from CDDP-induced damage through increased mt2 expression, which is a resistance mechanism for platinum-based anticancer drugs.

Keyphrases

oxidative stress
poor prognosis
single cell
high glucose
drug induced
cell therapy
low dose
high dose
long non coding rna
stem cells
endothelial cells