The T Cell Immunoscore as a Reference for Biomarker Development Utilizing Real-World Data from Patients with Advanced Malignancies Treated with Immune Checkpoint Inhibitors.

Islam EljilanyPayman Ghasemi SaghandJames L Chen Aakrosh Ratan Martin D McCarterJohn CarptenHoward ColmanAlexandra P IkeguchiIgor PuzanovSusanne ArnoldMichelle ChurchmanPatrick HwuJose Conejo-GarciaWilliam S DaltonGeorge J Weiner Issam El NaqaAhmad A Tarhini

Published in: Cancers (2023)

Calculating CD3+ and CD8+ T cell immunoscore using real-world transcriptomic data represents a promising signature for estimating OS with ICIs and can be used as a reference for future machine learning-based biomarker development.

Keyphrases

machine learning
big data
electronic health record
artificial intelligence
data analysis