Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells.
Jonas KathClemens FrankeVanessa DrosdekWeijie DuViktor GlaserCarla Fuster-GarcíaMaik SteinTatiana ZittelSarah SchulenbergCaroline E PorterLena AnderschAnnette KünkeleJoshua AlcanizJens HoffmannHinrich AbkenMohamed Abou-El-EneinAxel PrußMasataka SuzukiToni CathomenRenata StripeckeHans-Dieter VolkPetra ReinkeMichael Schmueck-HenneresseDimitrios Laurin WagnerPublished in: bioRxiv : the preprint server for biology (2023)
ζ-editing platform allows CAR reprogramming of NK cells without affecting their canonical functions.