Intra-Articular Injection of Rebamipide-Loaded Nanoparticles Attenuate Disease Progression and Joint Destruction in Osteoarthritis Rat Model: A Pilot Study.

Sung Eun KimSung Jae ChoiKyeongsoon ParkHak-Jun KimGwan Gyu SongJae Hyun Jung

Published in: Cartilage (2022)

Using a chemically induced rat model of OA, intra-articular delivery of rebamipide was associated with decreased local and systemic inflammatory response decreased joint degradation and arthritic progression.

Keyphrases

inflammatory response
knee osteoarthritis
high glucose
drug delivery
diabetic rats
drug induced
rheumatoid arthritis
lipopolysaccharide induced
lps induced
cancer therapy
ultrasound guided
clinical trial
oxidative stress
randomized controlled trial
wound healing
walled carbon nanotubes