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RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.

Kayleah M MenesesPrita PandyaJennifer A LindemannDania S Al-QasrawiRyan A ArgoCeleste M WeemsDanielle J BeetlerGeraldine V VijayIrene K YanJoy WolframTushar C PatelVerline Justilien
Published in: Cancer research communications (2023)
Expression of RAB27B in CSCs leads to elevated levels of EVs that mediate communication between CSCs and BCCs that maintains a stem-like phenotype in NSCLC cells.
Keyphrases
  • cancer stem cells
  • induced apoptosis
  • small cell lung cancer
  • cell cycle arrest
  • advanced non small cell lung cancer
  • poor prognosis
  • oxidative stress
  • cell death
  • signaling pathway
  • binding protein
  • pi k akt