Induction of microtubule hyper stabilization and robust G2 /M arrest by N-4-CN in human breast carcinoma MDA-MB-231 cells.
Prachi VermaNaresh Kumar ManchukondaSrinivas KantevariManu LopusPublished in: Fundamental & clinical pharmacology (2021)
Owing to its ability to perturb a well-defined cancer drug target, tubulin, and to promote ROS-facilitated apoptosis, N-4-CN could be investigated further as a potential therapeutic against many neoplasms, including TNBC.
Keyphrases
- cell cycle arrest
- cell death
- lymph node metastasis
- papillary thyroid
- pi k akt
- induced apoptosis
- endothelial cells
- endoplasmic reticulum stress
- oxidative stress
- squamous cell
- dna damage
- cell cycle
- induced pluripotent stem cells
- signaling pathway
- squamous cell carcinoma
- reactive oxygen species
- pluripotent stem cells
- emergency department
- high resolution
- drug induced
- cell proliferation
- young adults
- childhood cancer