Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.

Matan SorekWalaa OweisMalka Nissim-RafiniaMoria MamanShahar SimonCynthia C HessionXian AdiconisSean K SimmonsNeville E SanjanaXi ShiCongyi LuJen Q PanXiaohong XuMahmoud A PouladiLisa M EllerbyFeng ZhangJoshua Z LevinEran Meshorer

Published in: Genome biology (2021)

Overall, our results suggest that although neurodegenerative diseases develop over time, transcriptional regulation imbalance is present already at very early developmental stages. Therefore, an intervention aimed at this early phenotype may be of high diagnostic value.

Keyphrases

randomized controlled trial
gene expression
transcription factor
genome wide
dna methylation
oxidative stress
blood brain barrier