APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids.

Jing ZhaoTadafumi C IkezuWenyan LuJesse R MacyczkoYonghe LiLaura J Lewis-TuffinYuka A MartensYingxue RenYiyang ZhuYan W AsmannNilüfer Ertekin-TanerTakahisa KanekiyoGuojun Bu

Published in: Stem cell research & therapy (2023)

Our work demonstrates critical roles of apoE in brain homeostasis and offers critical insights into the APOE4-related pathogenic mechanisms.

Keyphrases

cognitive decline
induced pluripotent stem cells
high fat diet
endothelial cells
mild cognitive impairment
cerebral ischemia
white matter
subarachnoid hemorrhage
adipose tissue
insulin resistance
pluripotent stem cells
multiple sclerosis