The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer.
Ekaterina Mikhailovna StasevichMatvey Mikhailovich MurashkoLyudmila Sergeevna ZinevichDenis Eriksonovich DeminAnton Markovich SchwartzPublished in: Biomedicines (2021)
Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. Thus, controlling the expression of MYC is considered as an approach for targeted cancer treatment. Since c-Myc is also a crucial regulator of many cellular processes in healthy cells, it is necessary to find ways for selective regulation of MYC expression in tumor cells. Many recent studies have demonstrated that non-coding RNAs play an important role in the regulation of the transcription and translation of this gene and some RNAs directly interact with the c-Myc protein, affecting its stability. In this review, we summarize current data on the regulation of MYC by various non-coding RNAs that can potentially be targeted in specific tumor types.
Keyphrases
- transcription factor
- cell cycle arrest
- poor prognosis
- induced apoptosis
- immune response
- copy number
- binding protein
- endoplasmic reticulum stress
- cell death
- oxidative stress
- genome wide identification
- genome wide
- long non coding rna
- gene expression
- vascular endothelial growth factor
- squamous cell carcinoma
- single cell
- pi k akt
- mesenchymal stem cells
- machine learning
- big data
- dna methylation
- cell proliferation
- cell therapy
- artificial intelligence
- lymph node metastasis
- data analysis