Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment.
Pol Andrés-BenitoEllen GelpíMariona JovéNatalia Mota-MartorellElia ObisManuel Portero-OtinMònica PovedanoAurora PujolReinald PamplonaIsidro FerrerPublished in: Neuropathology and applied neurobiology (2021)
Globally, lipid alterations in the human frontal cortex of the ALS-FTLD-TDP43 proteinopathy spectrum, which involve cell membrane composition and signalling, vulnerability against cellular stress and possible glucose metabolism, are partly related to peroxisome impairment.