Photocatalytic aerobic α-thiolation/annulation of carbonyls with mercaptobenzimidazoles.

Xiaochen JiMuyun TanMei FuXiao-Lan Chen Hua-Wen Huang

Published in: Organic & biomolecular chemistry (2019)

A concise aerobic photocatalysis using a blue LED combined with a Lewis acid has been developed to enable α-thiolation/annulation of carbonyls. Inexpensive, nontoxic Rose Bengal was demonstrated as the best catalyst. Hence, this transition-metal-free protocol allows mild Csp3-S couplings with both ketones and aliphatic aldehydes with a range of compatible useful functionalities.

Keyphrases

visible light
high intensity
reduced graphene oxide
highly efficient
randomized controlled trial
light emitting
ionic liquid
room temperature
carbon dioxide
metal organic framework