PNPLA3 148M/M Is More Susceptible to Palmitic Acid-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells.

Yunzhi ChenXuemei YanTian WangHongrong DengXiaojie DengFen Xu Hua Liang

Published in: International journal of endocrinology (2023)

PNPLA3 148M/M cells were more susceptible to PA-induced lipid deposition and ER stress-related apoptosis than 148I/I cells, and the proapoptotic susceptibility of PNPLA3 148M/M is independent of LPC.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
cell cycle arrest
oxidative stress
cell death
pi k akt
signaling pathway
diabetic rats
high glucose
cell proliferation
endothelial cells
fatty acid