GAAGs, COMP, and YKL-40 as Potential Markers of Cartilage Turnover in Blood of Children with Juvenile Idiopathic Arthritis Treated with Etanercept-Relationship with ADAMTS4, ADAMTS5, and PDGF-BB.
Klaudia DąbkowskaMagdalena WojdasKornelia Kuźnik-TrochaGrzegorz WisowskiAnna GruenpeterKatarzyna Komosinska-VassevKrystyna OlczykKatarzyna Winsz-SzczotkaPublished in: Journal of clinical medicine (2022)
The dynamics of changes in marker concentrations during treatment seem to indicate that measurement of COMP and YKL-40 levels can be used to assess the chondroprotective biological efficacy of therapy. In contrast, changes in GAAGs concentrations reflect systemic extracellular matrix transformations in the course of JIA.
Keyphrases
- juvenile idiopathic arthritis
- extracellular matrix
- disease activity
- magnetic resonance
- young adults
- growth factor
- bone mineral density
- systemic lupus erythematosus
- rheumatoid arthritis
- smooth muscle
- stem cells
- vascular smooth muscle cells
- newly diagnosed
- rheumatoid arthritis patients
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- postmenopausal women
- mesenchymal stem cells
- drug induced
- smoking cessation