Assessment of body composition in the advanced stage of castration-resistant prostate cancer: special focus on sarcopenia.
Judith Stangl-KremserRodrigo Suarez-IbarrolaDavid D' AndreaStephan M KornMario PonesGero KramerMaximilian MarholdMichael KrainerDmitry V EnikeevPetr V GlybochkoDietmar TamandlShahrokh F ShariatPascal BaltzerPublished in: Prostate cancer and prostatic diseases (2019)
The large majority of men with CRPC suffers from sarcopenia. In our cohort, low skeletal muscle volume was an independent adverse prognosticator for progression of disease. We could not detect a statistically significant body composition parameter for OS, although patients with a high proportion of visceral fat had a trend for shorter OS. However, we suggest that body composition parameters determined by CT data can provide useful objective prognostic factors that may support tailored treatment decision-making.
Keyphrases
- body composition
- skeletal muscle
- prognostic factors
- resistance training
- insulin resistance
- bone mineral density
- decision making
- adipose tissue
- computed tomography
- electronic health record
- image quality
- magnetic resonance imaging
- contrast enhanced
- big data
- community dwelling
- metabolic syndrome
- fatty acid
- high intensity