In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival.

Luis P B GuerzoniValérie NicolasAngelina Angelova

Published in: Pharmaceutical research (2016)

Over time, dual drug formulations (curcumin and docosahexaenoic acid (DHA)) promoted the neuronal survival and repair processes through enhanced BDNF secretion and increased phosphorylation of CREB as compared to untreated degenerating cells.

Keyphrases

fatty acid
induced apoptosis
free survival
drug delivery
cell cycle arrest
cerebral ischemia
oxidative stress
signaling pathway
endoplasmic reticulum stress
protein kinase
wound healing
subarachnoid hemorrhage