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In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.

Xavier PilloisPierre PetersKarin SegersPaquita Nurden
Published in: Molecular genetics & genomic medicine (2018)
It appears that the αIIb genu is the object of stringent quality control to prevent platelets from circulating with activated and extended integrin.
Keyphrases
  • quality control
  • endothelial cells
  • cell adhesion
  • molecular docking
  • induced pluripotent stem cells
  • working memory
  • cell migration
  • copy number
  • pluripotent stem cells
  • gene expression
  • dna methylation