A framework for extending trial design to facilitate missing data sensitivity analyses.

Alexina J MasonRichard D GrieveAlvin Richards-BellePaul R MounceyDavid A HarrisonJames R Carpenter

Published in: BMC medical research methodology (2020)

Future studies can adopt this framework to embed expert elicitation within the design of clinical trials. This will provide the information required for MNAR sensitivity analyses that examine the robustness of the trial conclusions to alternative, but realistic assumptions about the missing data.

Keyphrases

clinical trial
phase iii
phase ii
study protocol
electronic health record
big data
open label
randomized controlled trial
artificial intelligence
deep learning