Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes.

Carmine ManconeAlessio GrimaldiGiulia RefoloIsabella AbbateGabriella RozeraDario BenelliGian Maria FimiaVincenzo BarnabaMarco TripodiMauro PiacentiniFabiola Ciccosanti

Published in: Proteome science (2017)

Our study indicates that HIV-1 cofactors influenced by iron metabolism represent potential targets for antiretroviral therapy and suggests eIF5A as a selective target for drug development.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
hiv infected patients
hiv testing
poor prognosis
men who have sex with men
iron deficiency
south africa
binding protein
risk assessment