Prospective manipulation of the gut microbiome with microbial ecosystem therapeutic 4 (MET4) in HPV-related locoregionally-advanced oropharyngeal cancer squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation: ROMA2 study.
Marc OlivaAlya HeiraliGeoffrey WatsonAshley M RooneyKyla CochraneSarah JenningsRachel TaylorMinge XuAli HosniAndrew HopeScott V BratmanDouglas ChepehaIlan WeinrebBayardo Perez-OrdonezRicard Mesia NinJohn WaldronWei XuAaron R HansenLillian L SiuBryan CoburnAnna SpreaficoPublished in: British journal of cancer (2024)
ROMA-2 did not meet its primary ecologic endpoint, as no engraftment was observed in the overall cohort. Exploratory findings of engraftment in stage III patients warrants further investigation of microbiome interventions in this subgroup.
Keyphrases
- squamous cell carcinoma
- end stage renal disease
- ejection fraction
- newly diagnosed
- papillary thyroid
- locally advanced
- physical activity
- peritoneal dialysis
- prognostic factors
- rectal cancer
- microbial community
- lymph node metastasis
- randomized controlled trial
- high grade
- risk assessment
- hematopoietic stem cell
- human health
- study protocol
- drug induced
- phase iii