ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment.

Huizhi SunJing MoRunfen ChengFan LiYue LiYuhong GuoYanlei LiYanhui ZhangXiaoyu BaiYalei WangXueyi DongDanfang Zhang Baocun Sun

Published in: Cancer biology & medicine (2022)

Hypoxia-induced ENO1 expression promotes ERK phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC.

Keyphrases

poor prognosis
cell proliferation
signaling pathway
stem cells
oxidative stress
binding protein
protein kinase
endoplasmic reticulum stress
cell death
risk assessment