Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma.
Marie-Thérèse AloyJacqueline Sidi BoumedineAgathe DevilleDavid KryzaArnaud GauthierDelphine Brichart-VernosGrégoire OllierVeronica La PadulaFrançois LuxOlivier TillementClaire Rodriguez-LafrasseMarc JanierPublished in: International journal of nanomedicine (2022)
These results provide the first proof of concept of the radiosensitizing effect of GdoNP in CHSs and opened the way for a multicentre, randomized Phase 2 trial evaluating the association of GdoNP with radiotherapy for the therapeutic management of patients with symptomatic inoperable musculoskeletal tumor lesions.
Keyphrases
- oxide nanoparticles
- double blind
- locally advanced
- early stage
- clinical trial
- single cell
- radiation therapy
- squamous cell carcinoma
- placebo controlled
- study protocol
- cell therapy
- magnetic resonance imaging
- cross sectional
- phase ii
- magnetic resonance
- radiation induced
- mesenchymal stem cells
- bone marrow
- contrast enhanced