Optimizing Arsenic Therapy by Selectively Targeting Leukemia Cells.
Judith A CarrallWilford LieJacob M LambertHugh H HarrisBarry LaiCarolyn T DillonPublished in: Journal of medicinal chemistry (2023)
Arsenic, in the simple form of arsenic trioxide, is currently marketed for the treatment of acute promyelocytic leukemia. Due to the multifaceted mechanisms of action of arsenic, it has also shown promise in other types of leukemias but is hindered by its toxic effects toward normal cells. This research has aimed to determine whether tumor-homing peptide complexes of arsenic can be designed and developed to strategically target specific cancers. The end goal is to achieve dose reduction and decreased side effects of the resultant arsenic therapeutic agent. In this article, we present the synthesis, characterization, and stability studies of a new class of As-peptide complexes designed to target leukemia. In vitro biological studies of the most stable complex show 1000 times greater toxicity toward leukemia cells over human blood cells, indicating potential for progression to in vivo studies.
Keyphrases
- induced apoptosis
- drinking water
- cell cycle arrest
- heavy metals
- acute myeloid leukemia
- bone marrow
- oxidative stress
- machine learning
- mesenchymal stem cells
- cell proliferation
- cancer therapy
- artificial intelligence
- young adults
- climate change
- big data
- extracorporeal membrane oxygenation
- combination therapy
- pluripotent stem cells