Toll-like receptor-induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma.
Damian TworekD HerouxS N O'ByrneP MitchellP M O'ByrneJ A DenburgPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
These data demonstrate an interaction between allergen and TLR ligand exposure in asthmatics. Allergen inhalation augments the TLR-induced inflammatory response by HPC, possibly leading to increased "in situ haemopoiesis" through up-regulation of TSLPR. These findings show that HPC may be a part of the pro-inflammatory cascade in pathogen-induced asthma exacerbation through their increased responsiveness to TLR stimulation.
Keyphrases
- toll like receptor
- inflammatory response
- chronic obstructive pulmonary disease
- high glucose
- nuclear factor
- allergic rhinitis
- immune response
- diabetic rats
- lipopolysaccharide induced
- lps induced
- drug induced
- poor prognosis
- oxidative stress
- endothelial cells
- intensive care unit
- electronic health record
- binding protein
- artificial intelligence
- cystic fibrosis
- stress induced