An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.

Liuyang WangThomas J BalmatAlejandro L AntoniaFlorica J ConstantineRicardo HenaoThomas W BurkeAndy InghamMicah T McClainEphraim L TsalikEmily R KoGeoffrey S GinsburgMark R DeLongXiling ShenChristopher W WoodsElizabeth R HauserDennis C Ko

Published in: Genome medicine (2021)

Thus, connecting genetically related traits across phenotypic scales links human diseases to molecular and cellular measurements that can reveal mechanisms and lead to novel biomarkers and therapeutic approaches. The iCPAGdb web portal is accessible at http://cpag.oit.duke.edu and the software code at https://github.com/tbalmat/iCPAGdb .

Keyphrases

endothelial cells
genome wide
coronavirus disease
sars cov
single cell
induced pluripotent stem cells
pluripotent stem cells
dna methylation
single molecule
drug induced