Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.
Chiara DentoneDaniela FenoglioAlessia ParodiTiziana AltosoleAntonio Di BiagioFederica BozzanoGiorgia NasiAntonio VenaMarina FabbiFrancesca FerreraBianca BruzzoneMauro GiacominiDaniele Roberto GiacobbePaolo PelosiAndrea De MariaMatteo BassettiRaffaele De PalmaGilberto FilaciPublished in: Clinical and experimental medicine (2022)
Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.
Keyphrases
- dendritic cells
- sars cov
- peripheral blood
- end stage renal disease
- inflammatory response
- ejection fraction
- newly diagnosed
- poor prognosis
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- hiv positive
- oxidative stress
- peritoneal dialysis
- hepatitis c virus
- prognostic factors
- endothelial cells
- hiv aids
- immune response
- machine learning
- early onset
- patient reported outcomes
- south africa
- deep learning
- artificial intelligence