Examining the Lancet Commission risk factors for dementia using Mendelian randomisation.
Roopal DesaiAmber JohnRob SaundersNatalie L MarchantJoshua E J BuckmanGeorgina CharlesworthVerena ZuberJoshua StottPublished in: BMJ mental health (2023)
Post hoc analysis indicated that the apparent protective effects of smoking, obesity and blood pressure were a result of survivor bias. The findings from this study did not support those presented by the Lancet Commission. Evidence from causal inference studies should be considered alongside evidence from epidemiological studies and incorporated into reviews of the literature.
Keyphrases
- blood pressure
- case control
- metabolic syndrome
- systematic review
- insulin resistance
- type diabetes
- mild cognitive impairment
- weight loss
- single cell
- hypertensive patients
- cognitive impairment
- heart rate
- weight gain
- randomized controlled trial
- diffusion weighted imaging
- meta analyses
- glycemic control
- contrast enhanced