Dexmedetomidine modulates mitochondrial dynamics to protect against endotoxin-induced lung injury via the protein kinase C-ɑ/haem oxygenase-1 signalling pathway.

Kai SongJia ShiLina ZhanQiaoying GaoJing YangShuan DongYuan ZhangJian-Bo Yu

Published in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2022)

Dexmedetomidine may activate the PKC-ɑ/HO-1 pathway to increase the expression of Mfn1, Mfn2, and OPA1, while decreasing Drp1 and Fis1 expression, thereby reduce endotoxin-induced acute lung injury.

Keyphrases

poor prognosis
high glucose
protein kinase
diabetic rats
oxidative stress
cardiac surgery
lipopolysaccharide induced
endothelial cells
inflammatory response
signaling pathway