Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice.
Torsten SchröderAnna V WieseFanny EnderKatharina M QuellTillman VollbrandtJannis DuhnAnnika SünderhaufAxel KünstnerMaria E Moreno-FernandezStefanie DererZouhair AherrahrouIan P LewkowichSenad DivanovicChristian SinaJörg KöhlYves LaumonnierPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
These findings suggest that short-term HFD feeding attenuates the development of AHR, airway inflammation, pulmonary DC recruitment and MHC-II/CD40 expression leading to diminished Th1/17 but unchanged Th2 differentiation. Thus, short-term HFD feeding and associated metabolic alterations may have protective effects in allergic asthma development.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- allergic rhinitis
- chronic obstructive pulmonary disease
- poor prognosis
- lung function
- pulmonary hypertension
- dendritic cells
- type diabetes
- metabolic syndrome
- skeletal muscle
- cystic fibrosis
- immune response
- high fat diet induced
- air pollution
- long non coding rna
- wild type