Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients.
Youngmee KimCharles S CarverJoachim F HallmayerJamie M ZeitzerOxana PaleshEric NeriBita NourianiDavid SpiegelPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2017)
Findings provide the first evidence that low serotonergic function contributes to both depression and impulsivity within a clinically meaningful sample. Furthermore, the link of s allele of 5-HTTLPR to emotional impulsivity was mediated by depressive symptoms, particularly perceptions of social rejection. Findings have implications for advanced breast cancer patients' treatment decision.