A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder.

Jasmohan Singh BajajEdith A GavisAndrew FaganJames B WadeLeroy R ThackerMichael FuchsSamarth PatelBrian C DavisJill MeadorPuneet PuriMasoumeh SikaroodiPatrick M Gillevet

Published in: Hepatology (Baltimore, Md.) (2021)

This phase 1 trial shows that FMT is safe and associated with short-term reduction in alcohol craving and consumption with favorable microbial changes versus placebo in patients with alcohol-associated cirrhosis with alcohol misuse. There was also a reduction in AUD-related events over 6 months in patients assigned to FMT.

Keyphrases

alcohol use disorder
end stage renal disease
alcohol consumption
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
randomized controlled trial
clinical trial
patient reported outcomes
placebo controlled