Oral pyrroloquinoline quinone (PQQ) during pregnancy increases cardiomyocyte endowment in spontaneous IUGR guinea pigs.

Jordan MatternAndrew GemmellPaige E AllenKatherine E MathersTimothy R H Regnault Brian K Stansfield

Published in: Journal of developmental origins of health and disease (2023)

The negative influence of spIUGR on cardiomyocyte number, apoptosis, and collagen deposition during parturition can be suppressed by antenatal administration of PQQ to pregnant sows. These data identify a novel therapeutic intervention for irreversible spIUGR-associated cardiomyopathy.

Keyphrases

pregnant women
angiotensin ii
randomized controlled trial
oxidative stress
endoplasmic reticulum stress
electronic health record
heart failure
high glucose
cell cycle arrest
cell death
preterm birth
big data
wound healing
endothelial cells
data analysis
deep learning
signaling pathway